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A disadvantage of chemical-based contact lens care systems is

  1. Deposits of proteins

  2. Irritation

  3. Decreased permeability

  4. Increased comfort

The correct answer is: Irritation

Chemical-based contact lens care systems can sometimes lead to irritation because certain individuals may have sensitivities or reactions to the chemicals present in these solutions. This can cause discomfort, redness, or itching for the wearer. It is important to assess each patient's needs and consider alternative solutions if they experience irritation with a particular contact lens care system. The other options are not disadvantages commonly associated with chemical-based contact lens care systems.